2004-11-13T21:32:12Z
http://purl.lanl.gov:80/STB-RL/xmltape1/biosis_2004_2a722f42-3361-11d9-8858-e9c71e5e5244
info:lanl-repo/i/00045206-3363-11d9-baf4-9e531f7bac73
2004-11-10T21:53:47Z
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collection:info*3Asid*2Flibrary.lanl.gov*3Abiosis
info:lanl-repo/pro/ai
info:lanl-repo/biosis/PREV200400435595
copyright BIOSISinfo:lanl-repo/pro/metadatahttp://purl.org/dc/terms/bibliographicCitationinfo:sid/library.lanl.gov:biosis
info:lanl-repo/fmt/32004-11-10T21:53:47Z
00000nab 2200000za 4500
PREV200400435595
2004-11-10
0196-9781
PREV200400435595
BIOSIS
eng
ISO639-2
86215
BIOSIS Controlled Vocabulary: Biosystematic Codes
154835-90-2
CAS Registry
195215-00-0
CAS Registry
10006
BIOSIS Controlled Vocabulary: Concept Codes
10060
BIOSIS Controlled Vocabulary: Concept Codes
12502
BIOSIS Controlled Vocabulary: Concept Codes
12512
BIOSIS Controlled Vocabulary: Concept Codes
14504
BIOSIS Controlled Vocabulary: Concept Codes
14506
BIOSIS Controlled Vocabulary: Concept Codes
15002
BIOSIS Controlled Vocabulary: Concept Codes
15004
BIOSIS Controlled Vocabulary: Concept Codes
22002
BIOSIS Controlled Vocabulary: Concept Codes
22005
BIOSIS Controlled Vocabulary: Concept Codes
22010
BIOSIS Controlled Vocabulary: Concept Codes
36002
BIOSIS Controlled Vocabulary: Concept Codes
Identification of an Adrenomedullin precursor fragment in plasma of sepsis patients
print
2004
1369-1372
25
8
1369-1372
Adrenomedullin and PAMP are potent vasodilatory peptides derived from a common larger precursor peptide. Elevation of circulating levels of both peptides has been described for diseases involving dysfunction of the cardiovascular system. However, the reliable quantification has been hampered by their short half-life times and - as known for Adrenomedullin - the existence of a binding protein. Here we report the identification of another peptide derived from the Adrenomedullin precursor, termed proADM 45-92, which is present in large concentrations in plasma of septic shock patients. This peptide is produced in stoichiometric amounts to Adrenomedullin and PAMP, but - contrary to them - is apparently non-functional and stable. Thus, proADM 45-92 represents a suitable diagnostic target which could be used to assess the concentrations of Adrenomedullin gene products released into the bloodstream. Copyright 2004 Elsevier Inc. All rights reserved.
English
Sepsis (MeSH)
Biochemistry and Molecular Biophysics
BIOSIS : MajorConcept : /Index/MajorConceptData[1]/MajorConceptList[1]/MajorConcept[1]
Cardiovascular Medicine
BIOSIS : MajorConcept : /Index/MajorConceptData[1]/MajorConceptList[2]/MajorConcept[1]
Human Medicine, Medical Sciences
BIOSIS : MajorConcept : /Index/MajorConceptData[1]/MajorConceptList[2]/MCBroaderTerms[1]
Clinical Chemistry
BIOSIS : MajorConcept : /Index/MajorConceptData[1]/MajorConceptList[3]/MajorConcept[1]
Allied Medical Sciences
BIOSIS : MajorConcept : /Index/MajorConceptData[1]/MajorConceptList[3]/MCBroaderTerms[1]
Infection
BIOSIS : MajorConcept : /Index/MajorConceptData[1]/MajorConceptList[4]/MajorConcept[1]
Pharmacology
BIOSIS : MajorConcept : /Index/MajorConceptData[1]/MajorConceptList[5]/MajorConcept[1]
Primates
BIOSIS : Taxonomy : /Index/TaxonomicData[1]/TaxonomicList[1]/SuperTaxa[1]
Mammalia
BIOSIS : Taxonomy : /Index/TaxonomicData[1]/TaxonomicList[1]/SuperTaxa[2]
Vertebrata
BIOSIS : Taxonomy : /Index/TaxonomicData[1]/TaxonomicList[1]/SuperTaxa[3]
Chordata
BIOSIS : Taxonomy : /Index/TaxonomicData[1]/TaxonomicList[1]/SuperTaxa[4]
Animalia
BIOSIS : Taxonomy : /Index/TaxonomicData[1]/TaxonomicList[1]/SuperTaxa[5]
Animals, Chordates, Humans, Mammals, Primates, Vertebrates
BIOSIS : Taxonomy : /Index/TaxonomicData[1]/TaxonomicList[1]/TaxaNotes[1]
Hominidae [86215]
BIOSIS : Taxonomy : /Index/TaxonomicData[1]/TaxonomicList[1]/OrgData[1]/OrgClassifier[1]
human
BIOSIS : Taxonomy : /Index/TaxonomicData[1]/TaxonomicList[1]/OrgData[1]/OrganismList[1]/OrganismName[1]
common
BIOSIS : Taxonomy : /Index/TaxonomicData[1]/TaxonomicList[1]/OrgData[1]/OrganismList[1]/TypeofName[1]
adrenomedullin
BIOSIS : Chemical : /Index/ChemicalData[1]/ChemicalList[1]/ChemicalName[1]
154835-90-2
BIOSIS : Chemical : /Index/ChemicalData[1]/ChemicalList[1]/CASRegistryNo[1]
cardiovascular-drug, vasodilator-drug
BIOSIS : Chemical : /Index/ChemicalData[1]/ChemicalList[1]/DrugModifier[1]
proadrenomedullin 45-92
BIOSIS : Chemical : /Index/ChemicalData[1]/ChemicalList[2]/ChemicalName[1]
proADM 45-92
BIOSIS : Chemical : /Index/ChemicalData[1]/ChemicalList[2]/ChemicalVariant[1]
cardiovascular-drug
BIOSIS : Chemical : /Index/ChemicalData[1]/ChemicalList[2]/DrugModifier[1]
proadrenomedullin N-terminal 20 peptide
BIOSIS : Chemical : /Index/ChemicalData[1]/ChemicalList[3]/ChemicalName[1]
PAMP
BIOSIS : Chemical : /Index/ChemicalData[1]/ChemicalList[3]/ChemicalVariant[1]
195215-00-0
BIOSIS : Chemical : /Index/ChemicalData[1]/ChemicalList[3]/CASRegistryNo[1]
cardiovascular-drug, vasodilator-drug
BIOSIS : Chemical : /Index/ChemicalData[1]/ChemicalList[3]/DrugModifier[1]
sepsis
BIOSIS : Disease : /Index/DiseaseData[1]/DiseaseList[1]/DiseaseTerm[1]
Sepsis (MeSH)
MeSH : /Index/DiseaseData[1]/DiseaseList[1]/MeSHTerm[1]
bacterial disease
BIOSIS : Disease : /Index/DiseaseData[1]/DiseaseList[1]/DiseaseAffiliation[1]
drug therapy, pathology, prevention and control
BIOSIS : Disease : /Index/DiseaseData[1]/DiseaseList[1]/DiseaseDetail[1]
cardiovascular system
BIOSIS : PartsStructure : /Index/PartsStructuresData[1]/PartsStructuresList[1]/PSTerm[1]
circulatory system
BIOSIS : PartsStructure : /Index/PartsStructuresData[1]/PartsStructuresList[1]/PSOrganSystem[1]
plasma
BIOSIS : PartsStructure : /Index/PartsStructuresData[1]/PartsStructuresList[2]/PSTerm[1]
blood and lymphatics
BIOSIS : PartsStructure : /Index/PartsStructuresData[1]/PartsStructuresList[2]/PSOrganSystem[1]
10006, Clinical biochemistry - General methods and applications
BIOSIS : ConceptCode : /Index/ConceptCodeList[1]/ConceptCode[1]
10060, Biochemistry studies - General
BIOSIS : ConceptCode : /Index/ConceptCodeList[1]/ConceptCode[2]
12502, Pathology - General
BIOSIS : ConceptCode : /Index/ConceptCodeList[1]/ConceptCode[3]
12512, Pathology - Therapy
BIOSIS : ConceptCode : /Index/ConceptCodeList[1]/ConceptCode[4]
14504, Cardiovascular system - Physiology and biochemistry
BIOSIS : ConceptCode : /Index/ConceptCodeList[1]/ConceptCode[5]
14506, Cardiovascular system - Heart pathology
BIOSIS : ConceptCode : /Index/ConceptCodeList[1]/ConceptCode[6]
15002, Blood - Blood and lymph studies
BIOSIS : ConceptCode : /Index/ConceptCodeList[1]/ConceptCode[7]
15004, Blood - Blood cell studies
BIOSIS : ConceptCode : /Index/ConceptCodeList[1]/ConceptCode[8]
22002, Pharmacology - General
BIOSIS : ConceptCode : /Index/ConceptCodeList[1]/ConceptCode[9]
22005, Pharmacology - Clinical pharmacology
BIOSIS : ConceptCode : /Index/ConceptCodeList[1]/ConceptCode[10]
22010, Pharmacology - Cardiovascular system
BIOSIS : ConceptCode : /Index/ConceptCodeList[1]/ConceptCode[11]
36002, Medical and clinical microbiology - Bacteriology
BIOSIS : ConceptCode : /Index/ConceptCodeList[1]/ConceptCode[12]
Article
BIOSIS : DocumentType : /DocumentTypeList/DocumentTypeText
Struck, Joachim
author
mailto:j.struck@brahms.de
Author, Reprint Author
Dept Res, BRAHMS Aktiengesellsch, Neuendorfstr 25, D-16761, Hennigsdorf, Germany
Tao, Chen
author
Author
Morgenthaler, Nils G.
author
Author
Bergmann, Andreas
author
Author
vol. 25, iss. 8
August 2004
Journal
25:8<1369
Peptides (New York)
0196-9781
url_ver=Z39.88-2004&rfr_id=info%3Asid%2Flibrary%2Elanl%2Egov%3Abiosis&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft_id=info%3Alanl%2Drepo%2Fbiosis%2FPREV200400435595&rft.issn=0196%2D9781&rft.aulast=Struck&rft.auinit1=J&rft.date=2004&rft.atitle=Identification%20of%20an%20Adrenomedullin%20precursor%20fragment%20in%20plasma%20of%20sepsis%20patients&rft.title=Peptides%20%28New%20York%29&rft.volume=25&rft.issue=8&rft.spage=1369&rft.epage=1372&rft.pages=1369%2D1372&rft.genre=article
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